HAS-1 Genetic Polymorphism in Sporadic Abdominal Aortic Aneurysm
نویسندگان
چکیده
منابع مشابه
HAS-1 genetic polymorphism in sporadic abdominal aortic aneurysm
The hyaluronan synthase 1 (HAS-1) gene encodes a plasma membrane protein that synthesizes hyaluronan (HA), an extracellular matrix molecule. Accumulating evidence emphasizes the relevance of HA metabolism in an increasing number of processes of clinical interest, including abdominal aortic aneurysm (AAA). The existence of aberrant splicing variants of the HAS-1 gene could partly explain the alt...
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Dear Editor,Abdominal aortic aneurysm is often asymptomatic, less recognized, and causes considerable mortality and morbidity, if missed. The incidence varies from country to country and the occurrence is influenced by modifiable (smoking, coronary heart disease, hypertension, dyslipidemia, and prolonged steroid therapy) and non-modifiable risk factors (increasing age, male gender, and positive...
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BACKGROUND Abdominal aortic aneurysm (AAA) is a life-threatening condition. A number of studies reported the association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and AAA risk, but substantial controversial findings were observed and the strength of the association remains unclear. OBJECTIVE The aim of this study was to investigate the aforementioned association i...
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phy. There was, therefore, a real increase in the incidIntroduction ence of abdominal aortic aneurysms. Smoking could be one of the risk factors. Auerbach [2] noted eight Acquired abdominal aortic aneurysms classically are times more abdominal aortic aneurysms in smokers characterized anatomically by an unparallelism of the than in non-smokers. Abdominal aortic aneurysms are aorta edges, result...
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ژورنال
عنوان ژورنال: Heart International
سال: 2009
ISSN: 1826-1868,2036-2579
DOI: 10.4081/hi.2009.e1